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This Clinical Focus discusses laboratory tests available to assist in differentiating RA from OA and other conditions that manifest with polyarthritis.
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One of the major long-term objectives of rheumatoid arthritis (RA) treatment is to prevent functional impairment as a result of bone damage, tendon or ligament rupture and cartilage breakdown.
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It is moderately effective in reducing the progression of the disease and the frequency of relapses in people after two years.
Linear IgA dermatosis is the most common autoimmune blistering disease in children.
Special ultrasound techniques called power Doppler ultrasonography (PDUS) or quantitative ultrasound (QUS) may be helpful in RA.
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Manifestations include: (i) chondritis of auricular, nasal, laryngo-tracheal, costal and joint cartilages, (ii) inflammation of the eyes and inner ear, (iii) collapse of laryngo-tracheal structures and structures in the subglottic area resulting in increased susceptibility to upper respiratory tract infections, and (iv) diversity of clinical manifestations, of the disease course and also of the treatment response.
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The exact cause of the CNS damage is unknown; however, inflammation and an inappropriate immune response likely play a key role in the pathogenesis.
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