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First, when the diagnosis of AD has been made, a cholinesterase inhibitor could be initiated, with or without memantine (in mild to moderate AD).

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Longitudinal Trajectories of Cognitive Change in Preclinical Alzheimer's Disease: A Growth Mixture Modeling Analysis.

Because of the instability of the symptoms of BPSD, many patients who are prescribed antipsychotics for neuropsychiatric symptoms will no longer need them when the drug is later discontinued ().

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The authors estimated the effects of each of the three commonly used drugs for Alzheimer disease ( donepezil, galantamine, and rivastigmine) in terms of predefined clinical outcomes and trial completion rates, by dosing level, and described differences among them.

The process of claim 1 wherein the said re-crystallizing comprises that the aqueous methanolic solution of donepezil hydrochloride is added to the methyl-tert-butyl-ether precipitating agent containing Polymorph (I) seeds.

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Remaining Gaps, Needs, and Opportunities: There is a need for both small, pilot studies and larger, robustly powered studies in this area.

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Other functional and structural imaging studies are beginning to uncover correlates of ASD differences in processing of visual and language inputs.

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Out of 648 patients enrolled to take the drug for 24 weeks, 11 died, while none of 326 patients in the placebo group did.

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The aim of this phase 2 study was to exploratively investigate the efficacy and safety of donepezil hydrochloride, in 3 different doses compared to placebo, in patients with DLB.

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AIM: To use comparative studies on the utilisation of the acetylcholinesterase inhibitors (AchE), galanthamine and donepezil, to evaluate the effectiveness and tolerance of the two drugs in the treatment of the symptoms of Alzheimer's disease (AD).

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In this case searching in MEDLINE by the author's name does not return the correction; neither does the citation listed within PUBMED or OVID indicate that a correction was issued.

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Measures of safety, assessed at specified intervals, included neurologic and physical examinations, measurement of vital signs, electrocardiography, laboratory tests (hematologic tests, blood chemical values, and urinalysis), and recording of adverse events.

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Of the nine objectives in Question 2, four objectives (addressing fever and immune system interactions with the central nervous system (CNS), biological pathways of genetic conditions related to autism, biological mechanisms of co-occurring conditions, and specific genotypes that underlie ASD phenotypes) met or exceeded the recommended budget and fulfilled the recommended number of projects.

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Disease that compared Donepezil hydrochloride 23 mg once daily to 10 mg once daily suggest that a 23 mg dose of Donepezil hydrochloride provided additional benefit.

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Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials.

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Sink KM, Holden KF, Yaffe K (2005), Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence.

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