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There is less evidence for lipid-lowering and aspirin therapy, although the benefits of these interventions for primary and secondary prevention are likely to apply to older adults whose life expectancies equal or exceed the time frames seen in clinical trials.

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In October 2007, after a mean of 30 months of treatment exposure and with data on 979 patients with primary adjudicated end points (59.

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The authors estimated that the additional reduction in BP produced by combining two drugs from different classes was approximately five times greater than that achieved by doubling the dosage of either drug.

The primary endpoint was the change from baseline in mean trough SeDBP (measured before taking the daily dose of study medication) after eight weeks of treatment in the intent-to-treat (ITT) population (patients with a BP measurement at baseline and at least one BP measurement after taking at least one dose of study medication) with last-observation-carried-forward (LOCF) imputation.

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