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Solian really works for people with Schizophrenia. We had experimented with almost every other psych medicine on the market over a period of seven years trying to help our younger daughter. Now she is on Solian for more than five months and she is functioning again. The paranoid and hysterical symptoms have disappeared completely. It is worth every penny I pay for the medication. She's been on antipsychotics for 5 years, and I have never seen such positive results in short time. Still no serious side effects.

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The present invention offers the ability to affect neuronal function by delivering the neuromodulator to vagal nerve-afferent or -efferent receptors in order to treat the CNS-related disorder.

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The composition of any of claims 31-64, wherein the at least one kind of cation comprises the cation of 2-aminothiazole, 6-azauridine, 6-mercaptopurine, 9-aminocamptothecin, acetarsone, acetazolamide, acetosulfone, acetylcysteine, acetylpheneturide, acranil, acrivastine, adrenalone, albutoin, aldioxa, alibendol, alizapride, alkofanone, allopurinol, ambenonium, ambroxol, ambutonium, amexinium, aminitrozole, amiphenazole, amisulpride, anagrelide, arsanilate, arshpenamine, asoxime, azidamfenicol, benfluorex, benfunolol, benserazide, benzaepril, benzilonium, benznidazole, benzoxonium, benzoylpas, berberine, bibenzonium, brequinar, brodimoprim, bromhexine, bromopride, bromo-salicylchloranilide, bucillamine, buformin, bufuralol, bumadizon, bunitrolol, buthalital, cabergoline, carbachol, carbarsone, carbidopa, cariporide, carnitine, caroxazone, celecoxib, cephaeline, cetalkonium, chloguanide, chloramphenicol, chlordantoin, chlorisonclamine, chloroquine, cholic acid, choline, ciclonicate, cilostazol, cimetidine, cinepazide, cinitapride, cisapride, clanobutin, clometocillin, clomiphene, cloricromen, clortermine, cyamelide, cyclazocine, dapsone, dimefline, diphetarsone, distigmine, dithiazanine, donepezil, dopamine, echothiophate, edrophonium, efavirenz, elfomithine, enfenamic acid, etifoxine, etodroxizine, fampridine, fazadinium, fendiline, fenproporex, finasteride, flufenamic acid, flumethiazide, fluoxetine, flurazepam, flutamide, fomepizole, fominoben, hexafluorenium, hydroxystilbamidine, ibudilast, indalpine, indeloxazine, ipratropium, irsogladine, isobutyl p-aminobenzoate, isoetharine, levosimendan, lisuride, lodoxamide, mesalamine, mesoxalate, metformin, methionine, methoxyphenamine, methyl hexaneamine, methylene blue, methylthiouracil, metrons, metyrosine, minoxidil, nadoxolol, nafronyl, naphazoline, naratriptan, neostigmine, nicametate, niclosamide, nicorandil, nilutamide, niridazole, nitazoxanide, nordefrin, obidoxime, omapatrilat, orotic acid, oxaceprol, oxitropium, ozagrel, pamidronic acid, p-aminobenzoic acid, p-aminopropiophenon, pelletierine, pemoline, penicillamine, pentamethonium, pentamidine, pentoxifylline, pergolid, perhexiline, phenmetrazine, phentolamine, phenylephrine, picotamide, pidotimod, pimobendan, pinacidil, pramipexole, prenylamine, prinomastat, pyridinol carbamate, pyridoxine, pyrimethamine, ramatroban, remoxipride, repinotan, riluzole, ritodrine, succinimide, succinylcholine, sulfamethoxazole, sulfapyridine, sulpiride, synephrine, tamsulosin, tedisamil, tenuazonic acid, terazosin, terbutaline, tetrazepam, tetroxoprim, thiabendazole, thiamine, thiopental, tiapride, timonacid, tiopronin, tiotropium, tizanidine, tolazoline, tropicamide, valnoctamide, zafirlukast, or a cationic derivative thereof.

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A4a are used herein as generic symbols to represent various specific substituents.

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Examples of those ionic liquid compositions include, but are not limited to, the mixture of at least two components of functionalized 5- and 6-membered, and bicyclic fused ring heterocyclic cations and anions containing 1, 2, 3, 4, or 5 atoms of nitrogen in the ring structure, where all carbon and nitrogen atoms in the ring structure can be functionalized with additional substituents such as alkyl, allyl, aryl, nitro, nitrile, azido, hydroxyl, carboxylic acid, ester, amide, amine, aldehyde, ketone, epoxy, or functionalized alkyl and aryl groups (with any functional mentioned above).

These exainples are not intended to be inclusive of all aspects of the subject matter disclosed herein, but rather to illustrate representative methods and results.

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Using the pharmaceutical composition of the present invention according to embodiments of methods herein may aid in accelerating bone fracture repair; attenuating protein catabolic response after a major operation; reducing cachexia and protein loss due to chronic illness; accelerating wound healing and accelerating the recovery of burn patients or of patients having undergone major surgery.

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The term "in conjunction with" means that when the CNS and the neuromodulators are administered in separate dosage forms, there is at least some chronological overlap in their physiological activity.

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The method of claim 35, wherein the CNS active agent has a time to maximum concentration (Tmax) and the mechanoreceptor stimulator has a Tmax, the delay in the administration or release of mechanoreceptor stimulator being equal to the Tmax of the CNS active agent minus the Tmax of the mechanoreceptor stimulator plus about 5 to about 30 minutes.

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In one embodiment, the sequence of the CNS active agent and Phenylephrine, or other Neuromodulator(s) is delayed at least 15-30 minutes so that Phenylephrine is administered after the CNS active agent to address hypertension while reducing the conventionally accepted effective dose of the CNS active agent by at least twice.

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Given that polymorphism and pseudo-polymorphism cannot be predicted; that the exact crystalline state affects chemical properties (e.

PSE) and other andrenergic receptor agonists) optimally reduce the side effects associated with a CNS agent when a mechanoreceptor stimulator (i.

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