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For drug users and their loved ones, though, the worry never ends. No day can be ordinary.

In its patient information leaflet, the Medicines and Healthcare products Regulatory Agency MHRA mentions a moderate increase in the risk of orofacial clefts if lamotrigine is used during pregnancy.

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The explanation for this difference may be as simple as the identification in the current study of a very specific, highrisk group of patients for which the intervention is effective.

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One of the two included trials in the Cochrane TENSreview reported a negative result, but this trial included patients with sciatica18 where the overview found both medication and other therapies to be largely ineffective.

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Okuno SH, Frytak S. Mitomycin lung toxicity. Acute and chronic phases. Am J Clin Oncol.

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Science 355, eaai8478 2017.

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Albany College of Pharmacy and Health Sciences, Albany, New York, accentuated the potential enhanced access to treatment afforded by biosimilars due to their lower cost.

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Or, as we prefer to call it, the National Vaccine MisInformation Center.

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