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Nervous system side effects (ototoxicity and peripheral neuropathy) have been reported after cyclophosphamide (the active ingredient contained in Cytoxan) was used with other antineoplastic agents (including cisplatin and carboplatin, drugs often associated with ototoxicity).

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SIADH (syndrome of inappropriate ADH secretion) has been reported with the use of cyclophosphamide.

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Marchetti suggested recommending that the patient return to the pharmacist in two to three weeks to discuss how the treatment was going.

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The primary objective of the study is to determine the overall efficacy response rate following treatment with Nipent, Cytoxan and Rituxan of patients with previously untreated or treated CLL.

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One, mesna was used in most patients, and there were a considerable number of pulse patients in this group, and it did correlate with reduced total doses of Cytoxan.

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Both studies were funded by Novartis Pharma AG, the maker of aliskiren.

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