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Signs of toxicity or cinchonism include tinnitus, headache, nausea, and slightly disturbed vision; usually disappear rapidly upon discontinuing quinine.
Coauthors on the study are Katharine Ozenberger of UIC and Columbia Universitys Mark Olfson.
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REVIEW: Malaria in pregnancy.
Quinine was the first drug to be associated with acute thrombocytopenia (), and it remains the second most commonly reported cause of drug-induced thrombocytopenia ().
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Quinine has been shown to decrease metabolism of desipramine in some patients (see Desipramine under Interactions) and may decrease metabolism of some other drugs that are CYP2D6 substrates (e.
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Patients were randomly assigned to receive either mefloquine or a combination of quinine plus SP (Metakelfin).
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