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Amiodarone has some uncommon traits together with a very long half-life of a number of weeks, and a relative lack of selectivity between a number of antiarrhythmic targets”. At therapeutic doses it blocks Na, K, and Ca channels, as well as α− and β-adrenergic receptors. It's in essence a nonselective antiarrhythmic shotgun”. While several of its multiple effects probably contribute to its scientific efficacy as an antiarrhythmic, its capacity to prolong the APD is taken into account to be most important” by many, hence its classification as Class III drug.
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