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Animal studies have shown reproductive toxicity in rats and rabbits.
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In a larger study evaluating 10 dogs diagnosed with meningoencephalomyelitis of unknown etiology, all dogs were treated with cyclosporine alone or in combination with steroids, ketoconazole, or both.
In our previous trial, we used Sandimmune (Novartis), whereas in the current trial we used CicloMulsion.
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CLARITHROMYCIN SHOULD NOT BE USED IN PREGNANT WOMEN EXCEPT IN CLINICAL CIRCUMSTANCES WHERE NO ALTERNATIVE THERAPY IS APPROPRIATE.
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When considering the development of Cyclosporine-associated nephropathy, it is noteworthy that several authors have reported an association between the appearance of interstitial fibrosis and higher cumulative doses or persistently high circulating trough concentrations of Cyclosporine.
Other uncommon effects include mild anaemia and leukocytosis.
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Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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In no patient did clinical side effects or alterations in laboratory values require the withdrawal of cyclosporine.
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