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Intensive treatment of blood sugar levels in some people with type 2 diabetes may cause serious complications, new research suggests.

Chronic metformin use results in vitamin B12 deficiency in 30% of patients.

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The morbidity associated with hypoglycemia, such as impaired consciousness and convulsions, can be particularly debilitating in the elderly, who are at increased risk of injury and bone fractures because of general frailty and the presence of comorbidities, such as osteoporosis ().

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Nanoparticles were found to deliver the drug into cells quickly and in higher quantity than when presented in solution and were found to result in a therapeutic efficacy comparable to the free drug.

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Parenthetically, hypoglycaemia as an undesirable side effect of diabetes therapy should be distinguished from the glucose concentration set as the lower limit to a therapeutic target, which is correctly set higher (e.

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In instances where the guidelines manual does not provide advice, additional methods were used and are described in detail.

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C-reactive protein, Interleukin-6, and posttraumatic stress disorder symptomology in urban police officers.

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Subgroup analyses indicated that younger pediatric patients aged 6 to 11 had efficacy results comparable to those of the older pediatric patients aged 12 to 14.

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Efficacy and safety of colesevelam in patients with type 2 diabetes mellitus and inadequate glycemic control receiving insulin-based therapy.

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Finally, sulfonylurea therapy was implicated as a potential cause of increased CVD mortality in the University Group Diabetes Program ().

November 2014 newspaper article suggested that a recent medical research breakthrough at (creating insulin-producing cells from ) could potentially put Novo Nordisk out of business.

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Benidipine prevents oxidative stress, inflammatory changes and apoptosis related myofibril damage in isoproterenol-induced myocardial infarction in rats.

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Repaglinide should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.

Efficacy and safety of treatment with sitagliptin or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy: a randomized, double-blind, non-inferiority trial.

CVD risk factors), since the potential adverse effects from bleeding likely offset the potential benefits.

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Because of metformin can cause hypoglycemia in nursing, a decision should be made whether to withdraw nursing or to discontinue the drug, taking into account the importance of the drug to the mothers health.

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The subject can have a disorder described herein, for example, metabolic syndrome, prediabetes, or type 2 diabetes.

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For patients on nonintensive insulin regimens, such as those with type 2 diabetes on basal insulin, when to prescribe SMBG and the testing frequency are unclear because there is insufficient evidence for testing in this cohort.

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Strojek K, Polaszewska-Muszynska M, Krassowski J, Grumprecht J, Rudzki H, Olejnizak H, Nazar M: Repaglinide versus sulfonylurea in combination with bedtime NPH insulin in patients with type 2 diabetes with secondary failure to oral treatment (Abstract).

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An association of self-reported severe hypoglycemia with 5-year mortality has also been reported in clinical practice ().

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