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Does Accutane stay in your system forever? It takes 5.5 x elimination half-life of a medicine before it is eliminated from your system. Accutane (isotretinoin) has an elimination half-life of 21 hours, therefore it will take 5.5 x 21 hours = 115.5 hours (approximately 4.8 days) before it will be cleared from your system. Side effects may last longer.
Does Accutane make acne worse before better? Unfortunately, when you first start using it, your acne may get worse before it gets better. Some of the more common side effects include dry skin and chapped lips. While taking isotretinoin, your skin will be more sensitive to the sun, so be sure to use sun protection. Don't use any type of indoor tanning device.
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