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My husband was diagnosed with moderate Alzheimer's disease in 2007. Since that time we have tried many medications that claimed to be effective in Alzheimer's treatment but in general they were useless. His condition was gradually getting worse and nothing really helped. About three months ago he started hallucinating and stopped recognizing the family members. It was unbearable to see him like that. So I asked our doctor to prescribe him with some new medication. We switched to Galantamine and it was pure luck! The hallucinations disappeared, memory came back and he started reacting better to things that used to confuse him before. I think this med is a god sent!
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Recently, biotechnology and pharmaceutical companies have attempted to extend the success of neurotrophin treatment found in animal models of AD to the clinic.

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Mutations in the genes for amyloid precursor protein (APP, on chromosome 21), presenilin 1 (PS1, chromosome 14), and presenilin 2 (PS2, chromosome 1) cause autosomal dominant early-onset AD.

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More than 90 clinical trials have evaluated galantamine's effect on Alzheimer's and other conditions.

Among the modalities that have been tried are immune serum globulin, rituximab, acyclovir, galantamine, fluoxetine and other antidepressants, methylphenidate and modafinil (stimulants), glucocorticoids, amantadine, doxycycline, magnesium, evening primrose oil, vitamin B12, Ampligen, essential fatty acids, bovine or porcine liver extract, dialyzable leukocyte extract, cimetidine, ranitidine, interferons, exclusion diets, BioBran MGN-3 (a natural killer cell stimulant), and removal of dental fillings.

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Investigational Drug Services at the University of Pennsylvania packaged galantamine hydrobromide extended release and placebo in matching capsules to ensure double-blind testing conditions.

Outcomes of interest include the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog), clinical global impression of change (CIBIC-plus or CGIC), Alzheimer's Disease Cooperative Study Activities of Daily Living Scale (ADCS-ADL), Disability Assessment for Dementia scale (DAD) and Neuropsychiatric Inventory (NPI).

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