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This medication is an angiotensin-converting enzyme (ACE) inhibitor, used alone or in combination with other medications to treat high blood pressure.
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It is of note that 30% of patients screened for entry into this study were already receiving ACE inhibitors, predominantly for the treatment of hypertension or as secondary prevention following myocardial infarction.
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HOPE, EUROPA), it may be inappropriate to discount their first-line use in the intermediate ejection fraction category, ie, patients with so-called diastolic dysfunction.
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Use: Reduce the risk of myocardial infarction, stroke, or death from cardiovascular causes in patients 55 years or older at high risk of developing a major cardiovascular event because of a history of coronary artery disease, stroke, peripheral vascular disease, or diabetes that is accompanied by at least one other cardiovascular risk factor (hypertension, elevated total cholesterol levels, low high-density lipoprotein (HDL) levels, cigarette smoking, or documented microalbuminuria); can be used in addition to other needed treatment such as antihypertensive, antiplatelet, or lipid lowering therapy.
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Clinical judgment is necessary for patients with diabetes who are younger than 50 years and have several other risk factors (for example, 10-year ASCVD risk of 5% to 10%).
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Safety data in the Heart Outcomes Prevention Evaluation (HOPE) study were collected as reasons for discontinuation or temporary interruption of treatment.
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